Inference of ventricular activation properties from twelve-lead electrocardiogram

Julia Camps1, Brodie Lawson2, Christopher Drovandi3, Ana Minchole1, Zhinuo Jenny Wang1, Vicente Grau1, Kevin Burrage3, Blanca Rodriguez1
1University of Oxford, 2ARC Centre of Excellence for Mathematical and Statistical Frontiers (Queensland University of Technology), 3Queensland University of Technology


The integration of cardiac magnetic resonance (CMR) imaging and electrocardiogram (ECG) data through advanced computational methods could enable the development of the cardiac ‘digital twin’, a comprehensive virtual tool that mechanistically reveals a patient’s heart condition from clinical data and simulates treatment outcomes. The adoption of cardiac digital twins requires the non-invasive efficient personalisation of the electrophysiological properties in cardiac models. This study develops and evaluates new computational techniques to estimate key ventricular activation properties for individual subjects by exploiting the synergy between CMR, ECG, and modelling and simulation. We present an efficient sequential Monte Carlo approximate Bayesian computation-based inference method, integrated with Eikonal simulations and torso-biventricular models constructed based on clinical CMR imaging to recover conduction speeds and earliest activation sites from 12-lead ECGs. We demonstrate successful results of our inference method on a cohort of twenty virtual subjects with cardiac ventricular myocardial-mass volumes ranging from 74 cm3 to 171 cm3.