Heart rate (HR) and heart-rate variability (HRV) are increasingly used to assess the body response to heavy physical effort and to define cardio-vascular risk indices for sport-related sudden cardiac death. The com-plexity of physiological phenomena affecting HR and HRV makes diffi-cult the interpretation of measures provided by commercial wearable technologies for athletes and trainers. Availability of interactive applica-tions for analysis of HR series can optimize continuous cardiac self-monitoring while training. This work proposes Sport?Sicuro!, a MATLAB® graphical user interface that allows automatic computation of prevention and performance indexes from HR series for cardiovascu-lar monitoring while practicing sport. Automatic analysis of HR series is based on fixed features definitions provided by literature, and other arbi-trary settings, the default values of which can be changed by the user. Eventually, Sport?Sicuro! provides a report file listing the quantitative results of the HR analysis presented in the output panel along with the plot of HR series (Figure). Colors help the identification of training phas-es and acceleration (green band) and deceleration (light blue band) on the HR series plot. The reference ranges of normality relative to each in-dex permit a first and rapid check of prevention indexes. These measures along with performance indexes can be examined in depth by including athlete’s data and training notes. The existent commercial applications for HR monitoring are finalized to assess athlete’s performance and their improvement. Whereas Sport?Sicuro! includes both performance indexes and cardiovascular risk indices for sport related sudden cardiac death, which is the leading medical cause of death across all sports and preven-tion by continuous screening remains the only weapon to contrast sport related sudden cardiac death. Thus, Sport?Sicuro! represents a potential-ly useful graphical tool for automatic and objective analysis of HR series in support to sport medicine clinicians and automatic self-monitoring of athletes during sport.