Electromechanical Coupling in Human Atrial Cardiomyocytes: Force-Frequency Relationship Study

Fazeelat Mazhar1, Francesco Regazzoni2, Chiara Bartolucci1, Cristiana Corsi1, Luca Dede2, Alfio Quarteroni3, Stefano Severi1
1University of Bologna, 2Politecnico di Milano, 3École Polytechnique Fédérale de Lausanne


Abstract

Electromechanical coupling is crucial for modeling a realistic representation of Calcium transient and Ca+2 cycling. Cellular Ca+2 dynamics in atria differ fundamentally from the ventricles. A biophysically detailed electrophysiology model is hence, necessary to reproduce the experimentally observed phenomena like Ca+2 wave propagation in human atrial myocytes. In this work, we present a spatially detailed and yet computationally efficient electrophysiology model and its coupling with a contraction myofilament model. Having this fully coupled and calibrated human atrial electromechanical model we can reproduce the rate adaptation property of action potential duration, Ca+2 transient and the active force. The aim of this article is to analyse the mechanism that is behind the rate adaptation for a fully coupled human atrial electromechanical model.