Dominant Frequency Estimation in AF from ECGI

Carlos Fambuena Santos1, Ismael Hernández-Romero2, Clara Herrero Martín3, Jana Reventós Presmanes4, Eric Invers Rubio5, Luis Mont5, Andreu M. Climent3, Maria de la Salud Guillem Sánchez3
1UPV, 2ITACA Institute, Universitat Politècnica de València, 3Universitat Politècnica de València, 4Arrhythmias Department, Hospital Clínic de Barcelona, 5Hospital Clinic de Barcelona


Non-invasive estimation of high-frequency activation regions in atrial fibrillation (AF) may have an important role in patient stratification and ablation guidance. This work presents a methodology to robustly estimate DF maps in ECGI, where the uncertainty associated to the estimates is modeled making use of a set of ECGI solutions obtained from Tikhonov 0-order regularization with a range of different lambda parameters (DF-LR). The proposed DF-LR method was compared to the DFs obtained from Tikhonov 0-order regularization when selecting the lambda value from the standard L-curve optimization method (DF-LC). Specifically, the highest dominant frequency (HDF) found with both methods was tested in 2 AF simulations where the gold standard activation frequencies were extracted from the simulated transmembrane potentials. In addition, the reproducibility of the DF maps were studied in a clinical case using ECGI signals from a persistent AF patient. In this case, the mean absolute difference between DF maps obtained in consecutive time windows was computed to quantify the reproducibility of the methods LC, LR, and LR in high confidence atrial regions. DF-LR method overcame the DF-LC in terms of HDF sensitivity (see table 1). Furthermore, the mean absolute difference between consecutive DF maps was lower in DF-LR method (0.64±0.34Hz vs 1.38±0.11 Hz) showing higher reproducibility.