Enhancing 2D Patient Specific Electrophysiology with Physics-Informed Neural Networks

Adam Jakobsen1, Vajira Thambawita2, Thu Nguyen2, Mary M Maleckar3, Gabriel Balaban3
1University of Oslo, Oslo Norway, 2SimulaMet, 3Simula Research Laboratory


Abstract

Background: Neural networks, once trained, can offer predictions for personalized cardiac electrophysiology (EP) within a very short timeframe. Physics-Informed Neural Networks (PINNs) can combine the theoretical knowledge of a physical system with data, presenting a promising method for personalized electrophysiology simulations. Methods: We have developed a PINN model that utilizes spatial and temporal coordinates along with local conductivities as input parameters to predict the spatio-temporal evolution of action potentials. 2D magnetic resonance images were used to establish a computational domain and infer local conductivities, providing a proof of concept for more detailed personalized 3-D models. Results: Our study illustrates the capability of PINNs to precisely recreate action potential dynamics from limited in-silico voltage data. Importantly, we show that trained PINNs can accurately interpolate and extrapolate with local conductivity inputs beyond the range of training data and make predictions at a significantly reduced time-frame.