Modelling Multi-phase Cardiac Anatomy with Generative Deep Learning

Thalia Seale1, Blanca Rodriguez1, Vicente Grau2, Abhirup Banerjee1
1University of Oxford, 2Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford


Abstract

The motion of the cardiac anatomy has a considerable influence on cardiac function and disease development. Previous contributions to the analysis of cardiac anatomy have mostly focussed on one or two phases from the cardiac cycle. However, a more complete understanding of cardiovascular disease could be achieved through the analysis and quantification of motion abnormalities in the anatomy over the full cardiac cycle. In this work, we propose a deep learning pipeline capable of reconstructing and generating continuous-time representations of the biventricular anatomy from a finite number of time points in the cardiac cycle. We demonstrate the proposed model provides interpretable quantification of geometric and motion characteristics of the anatomies. Our analysis of a dataset of 190 subjects shows that the reconstructions from the proposed model are accurate to sub-pixel resolution, with an average Chamfer distance of 1.71 (± 1.13) mm.