Postural Orthostatic Tachycardia Syndrome (POTS) is increasingly identi-fied as a long-term sequela of COVID-19 and is characterized by autonomic dysfunction and abnormal hemodynamic responses during postural changes. This study investigates systolic and diastolic blood pressure variability in patients with a history of COVID-19 and symptoms suggestive of POTS using a standardized tilt test protocol. A total of 56 volunteers (37 study group; 19 control) aged 18–75 years were evaluated. The tilt test protocol involved 15 minutes in supine position, 15 minutes in upright position (or-thostasis), and 20 minutes back in supine. Blood pressure was measured every minute using an automatic monitor. Heart rate and posture were con-currently recorded using smartwatches. Statistical analysis included Mann-Whitney tests and time-domain variability indices calculated using PysBio. The mean SBP-DBP difference was 41.4 ± 12.4 mmHg in the study group and 43.8 ± 10.1 mmHg in the control group. During the orthostatic phase, the SBP-DBP difference decreased similarly (35.5 ± 14.0 vs. 35.7 ± 8.5 mmHg), but variability was lower in the study group: SD = 6.76 ± 2.2 vs. 7.49 ± 2.7. Although not statistically significant, these results suggest reduced autonomic adaptation in the post-COVID-19 group. Comorbidities such as hypertension (19.6%) and obesity (14.3%) were more frequent in the post-COVID group. These preliminary findings support the hypothesis that POTS after COVID-19 is associated with subtle impairments in baroreflex-mediated cardiovas-cular control. Further investigations with multivariate analyses and increased sample size are ongoing.